The Adrenal Glands: Nature’s Roller Coaster or the Source of Your Fatigue?

Bandwagons. You’ve got to love them. But bandwagons are a dime a dozen.
Every industry has one and far too many people end up getting hurt when they try to
jump on them. The health industry is no different.
The problem with bandwagons is that they tend to offer overly simplistic
solutions to a complex problem. Vitamin D is a recent example of a health
industry bandwagon. Every week there is a new study demonstrating the importance
of Vitamin D in everything from depression to diabetes to cancer. And supposedly
supplementing with Vitamin D will fix all of this. Maybe it will, but I doubt
it. Answers are usually a little more complex than that.
The adrenal glands could also be considered a bandwagon of sorts because practitioners quickly assume they’re the cause of virtually every disease imaginable. But is focusing on the adrenal glands a legitimate approach when pursuing health, or a crude explanation for a much more complicated issue? Well… yes and yes.

A primer on the adrenal glands

The adrenal glands are small, triangular shaped glands that sit atop your
kidneys, hence their other name “suprarenal glands” (from the Latin
supra, or “above”). The adrenal glands regulate our body’s response to
stress in a number of ways.
There are two main sections of the adrenal glands: the outer adrenal cortex
and the inner adrenal medulla.
The adrenal cortex is further divided into three layers.
  • Zona glomerulosa – the site of mineralcorticoid production (i.e.
    aldosterone), which helps to regulate sodium/potassium balance in the body
  • Zona fasciculata – the site of glucocorticoid production (i.e. cortisol),
    which helps regulate blood sugar balance
  • Zona reticularis – the site of sex hormone production (i.e. DHEA,
(In medical school, one way we learned to remember these three layers is:
“Salt, sugar, sex… the deeper it goes, the sweeter it gets.” Not important, but

Holy instantaneous epinephrine blast, Batman!

The adrenal glands are unique in that part of them, the inner adrenal
medulla, has a direct connection to the brain. In virtually all of the other
hormone producing glands in the body, the message to secrete a hormone is
transmitted via a chemical messenger traveling through the blood stream. For
example, TSH, a hormone, tells the thyroid to produce thyroid hormone. ACTH, a
hormone, tells the adrenal cortex to secrete cortisol.
Not so with the adrenal medulla. There is a nerve that goes directly from the
brain to the adrenal glands. It’s like Commissioner Gordon’s red telephone to
Batman. This makes sense. When you are in an acute stress situation (perhaps
when the Penguin escapes), you want your body to respond quickly.

Adrenal glands gone awry

For simplicity’s sake, let’s break down adrenal function into two
  1. Overactive
  2. Underactive
Overactive adrenal glands usually produce too much cortisol and possibly
other adrenal hormones (i.e. epinephrine, aldosterone). Since cortisol plays a
role in elevating blood sugar, this is often accompanied by an increased blood
sugar level. Over time, this might end up leading to conditions like insulin
resistance and metabolic syndrome.
Underactive adrenal glands, on the other hand, produce inadequate amounts of
hormones, especially cortisol, to maintain homeostasis in the body. A common
clinical problem with underactive adrenal glands is hypoglycemic symptoms due to
fluctuations in blood sugar. Normal, healthy bodies release cortisol to help
liberate glucose to maintain the functions of our brain, organs and cells when
blood sugar levels decline between meals, or overnight during sleep. When
cortisol is unavailable, glucose levels get too low. The adrenal glands release
epinephrine (aka adrenaline) as their back-up plan. This causes the
lightheadedness, shakiness and irritability that people with low blood sugar
experience, and is why people with low blood sugar commonly wake up during the
What can cause dysfunctional adrenal glands? Unfortunately, a lot of things:
mental/emotional stress, food sensitivities, blood sugar imbalances, infections
(i.e. parasitic, bacterial), excessive exercise… basically anything that is a
perceived stress on the body.

Adrenal physiology in the 21st century

Forty years ago, medical practitioners thought that the adrenal glands went
through stages starting with overactivity (alarm phase), to a declining phase
(resistance phase) and finally to underactivity (exhaustion phase).
This is a logical model, but it doesn’t hold up to current research. We now
know that under the influence of certain biochemical processes, the adrenal
glands can go straight into a state of overactivity or underactivity without
going through the first two phases.
For instance, through a series of biochemical processes a viral infection can
throw the adrenal glands into a state of adrenal underactivity. On the other
hand, food sensitivities seem to encourage the body’s physiology to promote a
state of adrenal hyperactivity.

Testing adrenal gland function

Try this at home!

Here’s one relatively easy test to do if you have a blood pressure monitor.
It’s called the orthostatic hypotension test. After lying down for
approximately 5 minutes, take your blood pressure and make note of the systolic
pressure (the top number). Then stand up and take your blood pressure again.
If your systolic pressure remained the same or if it decreased, there is a
chance you do not have optimal adrenal medulla function, or epinephrine
secretion. When we stand, epinephrine is normally secreted to increase our blood
pressure to help prevent gravity from pulling blood away from our brain. If your
blood pressure drops, it might mean that epinephrine isn’t there to do its
Systolic change Possible finding
Increases 6-10 mm/Hg Healthy adrenal function
Does not change Fair adrenal function
Drops 1-10 mm/Hg Poor adrenal function
Drops more than 10 mm/Hg Adrenal exhaustion
Another at-home test you can do is called the paradoxical pupillary
. Standing in front of a mirror in a dark room, take a flashlight and
shine the light into one eye at a 45 degree angle from the side. Watch your
When in the dark, your pupil should be dilated (open). When you shine the
light it should constrict.  The duration of constriction can indicate
adrenal function, though there are other causes for a positive finding on this
test. Wait 30 seconds in the dark before repeating with the other eye. (If you
get bored while waiting, chew some wintergreen Lifesavers.)
Pupil constriction Possible finding
Stays constricted for at least 20 seconds Healthy adrenal function
Fasciculates (pulses) after 10 seconds Fair adrenal function
Fasciculates (pulses) in 5-10 seconds Poor adrenal function
Immediate pulsation and dilation Adrenal exhaustion

Laboratory testing

There are a few ways of assessing adrenal gland function using laboratory
testing. By far the most popular is the adrenal salivary test. It takes
four salivary samples throughout the day and uses them to assess levels of
salivary cortisol and DHEA. Along with patient history, symptomaology, and
clinical observation, the adrenal salivary test is one of the most effective
ways of assessing adrenal gland function and determining a course of

As an aside… before you use hormone replacement

In practice and even on the Precision Nutrition Forum, people often ask about
the use of hormone replacement. There are three things that must be
functioning properly before consideration of HRT:
  1. adrenal gland function
  2. blood sugar balance; and
  3. gastrointestinal function.
Here’s a short presentation demonstrating why.

Managing the adrenal glands

If you’re concerned about your adrenal glands, the first thing you must to is
remove or address the source of stress. This may mean removing food
sensitivities, addressing an infection, resolving mental/emotional stress, or
whatever it may be that is negatively impacting adrenal gland physiology.
Once you address the source of stress, these are some therapeutic options
depending on the findings of the adrenal salivary test:
  • Adaptogenic herbs – There are a number of botanicals called
    “adaptogens” because of their amazing ability to help the body respond to
    stress. They can help dampen the stress response in overactive adrenal glands,
    and increase the response in underactive adrenal glands.
  • Licorice root – This herb is used primarily in the case of
    underactive adrenal glands and can help with increasing circulating cortisol
    levels until the adrenal glands restore function. Due to its effects on
    aldosterone, it is not recommended for people with high blood pressure, though I
    think it can be safely used when monitored by a qualified medical professional.
  • Phosphytidylserine – This compound is best known for its
    ability to lower cortisol. But its effects are understated. PS should be used in
    both overactive adrenal glands and underactive adrenal glands because of its
    profound effects on the hypothalamus, which is a key regulator in the feedback
    loop between the pituitary and adrenal glands. Though 600-800 mg taken orally
    seems to be effective, I personally like using a topical application of PS to
    get even higher doses while keeping costs down.
  • Hormones – Even though I mildly bashed the use of hormone
    replacement, there are two hormones that are sometimes indicated when
    rehabilitating the adrenal glands: pregnenolone and DHEA. However, please don’t
    use them without the supervision of a qualified medical professional.


The adrenal glands and their hormones have major physiological impacts on our
body including bone metabolism, hormonal balance, gastrointestinal function,
thyroid function, brain health, blood sugar balance, inflammation, immune system
function, etc. But in today’s modern times, supporting one’s adrenal glands is
far more complicated than in the past. It requires proper testing, looking at
many different physiological systems in the body, and proper nutritional support
to help our body deal with stress. Unfortunately conventional medical doctors
know nothing about this and many alternative doctors are using adrenal gland
models that have become outdated.

About the author

Dr. Bryan P. Walsh is a Naturopathic Physician specializing in nutritional
biochemistry, functional laboratory testing and natural medicine. He is a guest
lecturer at the University of Maryland School of Medicine, has been a presenter
at national conferences.

Don Kirby

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